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Заявки на вступление в Клан KINGS (+40)
WilliamMrДата: Пятница, 24.06.2016, 13:00 | Сообщение # 151
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tcsgroupoДата: Среда, 29.06.2016, 18:20 | Сообщение # 152
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According to a 2005 article in the journal Drugs, docetaxel administered as a one-hour infusion every three weeks generally settled a ten cycle course, docetaxel is considered as or more real than doxorubicin, paclitaxel and fluorouracil as a cytotoxic agent.[1 - No matter what the effectiveness of docetaxel versus paclitaxel and other taxanes is still controversial. Several more current articles be suffering with initiate "no demonstration that regimens containing docetaxel raise the white flag greater benefits than those including paclitaxel."[6 - Additionally, the optimal scheduling of docetaxel and other taxanes remains unconfirmed. A three-week charge list hardened to be and is stationary considered efficient but fashionable studies are indicating a weekly register influence be better. A 2010 article in Current Clinical Pharmacology states, "weekly administration has emerged as the optimal schedule." Docetaxel is marketed worldwide comprised in the identify Taxotere during Sanofi-Aventis.[7 - Annual sales in 2010 were Euro 2.122 billion ($US 3.1 billion). The patent expired in 2010.[citation
Docetaxel is of the chemotherapy knock out class; taxane, and is a semi-synthetic analogue of paclitaxel (Taxol), an draw forth from the bark of the rare Pacific yew tree Taxus brevifolia.[2 - Due to paucity of paclitaxel, vast delving was carried visible unsurpassed to the formulation of docetaxel – an esterified yield of 10-deacetyl baccatin III, which is extracted from the renewable and gladly present European yew tree.
Docetaxel differs from paclitaxel at two positions in its chemical structure. It has a hydroxyl functional dispose on carbon 10, whereas paclitaxel has an acetate ester, and a tert-butyl carbamate ester exists on the phenylpropionate side string instead of the benzyl amide in paclitaxel. The carbon 10 functioning sort revolution causes docetaxel to be more water soluble than paclitaxel.[2 -
Formulations and compositions
Docetaxel is a snowy authority and is the working ingredient handy in 20 mg and 80 mg Taxotere single-dose vials of concentrated anhydrous docetaxel in polysorbate 80.[2 - [8 - The answer is a readable brown-yellow containing 40 mg docetaxel and 1040 mg polysorbate 80 per mL.[8 - 20 mg Taxotere is distributed in a blister carton containing harmonious single-dose vial of Taxotere (docetaxel) preparation in 0.5 mL disinfected pyrogen-free anhydrous polysorbate 80, and a only dosage Taxotere reliable vial containing 1.5 mL 13% ethanol in saline to be combined and diluted in a 250 mL infusion bag containing 0.9% sodium chloride or 5% glucose recompense administration.[8 - 80 mg Taxotere is supplied identically but with 2.0 mL polysorbate 80 and 6.0 mL 13% ethanol in saline. The docetaxel and reliable vials are combined to bestow a settling of 10 mg/mL and the required dose is tense from this solution. Vials have an overfill to compensate in compensation flowing set-back during preparation, foaming, adhesion to vial walls and the numb volume. 20 mg vials may be stored looking for 24 months under 25 °C away from understanding and 80 mg vials for 26 months in the yet conditions.[8 -
Recently Sanofi has got authorization in behalf of one-vial formulation.[citation needed - With this one-vial formulation, the preparation of the infusion emulsion is simplified alongside eliminating the fundamental dilution step. The two-vial and one-vial formulations carry the at any rate drug substance, docetaxel trihydrate, and the same excipients (ethanol, polysorbate 80 and citric acid). The one-vial formulation is administered as an aqueous intravenous result that contains the despite the fact numb burden in the unchanged concentration as the already approved two-vial formulation. The unvarying form, superiority, and measure of polysorbate 80 are closest in the infusion elucidation of both formulations. The only remainder between these two formulations is the volume of ethanol.
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ThomasdizДата: Четверг, 30.06.2016, 00:11 | Сообщение # 153
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BrkndonsLarfДата: Пятница, 01.07.2016, 15:53 | Сообщение # 158
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EvilpomДата: Понедельник, 04.07.2016, 16:01 | Сообщение # 160
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JoshabinaДата: Понедельник, 04.07.2016, 16:22 | Сообщение # 161
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MiltonhagoДата: Понедельник, 11.07.2016, 00:41 | Сообщение # 165
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Приветствую. Нашла текст по теме, но не могу победить каптчу. Что делать?
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